Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease Young Adult Study (HD-YAS): a cross-sectional analysis

BACKGROUND: Disease-modifying treatments are in development for Huntington's disease; crucial to their success is to identify a timepoint in a patient's life when there is a measurable biomarker of early neurodegeneration while clinical function is still intact. We aimed to identify this t...

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Pubblicato in:Lancet Neurol
Autori principali: Scahill, Rachael I, Zeun, Paul, Osborne-Crowley, Katherine, Johnson, Eileanoir B, Gregory, Sarah, Parker, Christopher, Lowe, Jessica, Nair, Akshay, O'Callaghan, Claire, Langley, Christelle, Papoutsi, Marina, McColgan, Peter, Estevez-Fraga, Carlos, Fayer, Kate, Wellington, Henny, Rodrigues, Filipe B, Byrne, Lauren M, Heselgrave, Amanda, Hyare, Harpreet, Sampaio, Cristina, Zetterberg, Henrik, Zhang, Hui, Wild, Edward J, Rees, Geraint, Robbins, Trevor W, Sahakian, Barbara J, Langbehn, Douglas, Tabrizi, Sarah J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lancet Pub. Group 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254065/
https://ncbi.nlm.nih.gov/pubmed/32470422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(20)30143-5
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