Brain Regions Showing White Matter Loss in Huntington’s Disease Are Enriched for Synaptic and Metabolic Genes

BACKGROUND: The earliest white matter changes in Huntington’s disease are seen before disease onset in the premanifest stage around the striatum, within the corpus callosum, and in posterior white matter tracts. While experimental evidence suggests that these changes may be related to abnormal gene...

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Gepubliceerd in:Biol Psychiatry
Hoofdauteurs: McColgan, Peter, Gregory, Sarah, Seunarine, Kiran K., Razi, Adeel, Papoutsi, Marina, Johnson, Eileanoir, Durr, Alexandra, Roos, Raymund A.C., Leavitt, Blair R., Holmans, Peter, Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803509/
https://ncbi.nlm.nih.gov/pubmed/29174593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.10.019
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