Topological length of white matter connections predicts their rate of atrophy in premanifest Huntington’s disease

We lack a mechanistic explanation for the stereotyped pattern of white matter loss seen in Huntington’s disease (HD). While the earliest white matter changes are seen around the striatum, within the corpus callosum, and in the posterior white matter tracts, the order in which these changes occur and...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: McColgan, Peter, Seunarine, Kiran K., Gregory, Sarah, Razi, Adeel, Papoutsi, Marina, Long, Jeffrey D., Mills, James A., Johnson, Eileanoir, Durr, Alexandra, Roos, Raymund A.C., Leavitt, Blair R., Stout, Julie C., Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J., Investigators, the Track-On HD
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396531/
https://ncbi.nlm.nih.gov/pubmed/28422761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92641
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