Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2

[Image: see text] Covalently acting inhibitors constitute a large and growing fraction of approved small-molecule therapeutics as well as useful tools for a variety of in vitro and in vivo applications. Here, we aimed to develop a covalent antagonist of CC chemokine receptor 2 (CCR2), a class A GPCR...

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Vydáno v:J Med Chem
Hlavní autoři: Ortiz Zacarías, Natalia V., Chahal, Kirti K., Šimková, Tereza, van der Horst, Cas, Zheng, Yi, Inoue, Asuka, Theunissen, Emy, Mallee, Lloyd, van der Es, Daan, Louvel, Julien, IJzerman, Adriaan P., Handel, Tracy M., Kufareva, Irina, Heitman, Laura H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2021
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958898/
https://ncbi.nlm.nih.gov/pubmed/33600174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01137
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