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Charting the sequence-activity landscape of peptide inhibitors of translation termination

Apidaecin (Api), an unmodified 18-amino-acid-long proline-rich antibacterial peptide produced by bees, has been recently described as a specific inhibitor of translation termination. It invades the nascent peptide exit tunnel of the postrelease ribosome and traps the release factors preventing their...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Baliga, Chetana, Brown, Tyler J., Florin, Tanja, Colon, Sarah, Shah, Vallari, Skowron, Kornelia J., Kefi, Amira, Szal, Teresa, Klepacki, Dorota, Moore, Terry W., Vázquez-Laslop, Nora, Mankin, Alexander S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958441/
https://ncbi.nlm.nih.gov/pubmed/33674389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2026465118
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