Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the cellular translation machinery and can be exploited for antibiotic discovery. Because cells have many different RS, usually one for each amino acid, identification of the specific enzyme targeted by a new natural or synth...

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Detaylı Bibliyografya
Asıl Yazarlar: Orelle, Cédric, Szal, Teresa, Klepacki, Dorota, Shaw, Karen J., Vázquez-Laslop, Nora, Mankin, Alexander S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2013
Konular:
Methods Online
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737564/
https://ncbi.nlm.nih.gov/pubmed/23761439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt526
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