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Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition
Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the cellular translation machinery and can be exploited for antibiotic discovery. Because cells have many different RS, usually one for each amino acid, identification of the specific enzyme targeted by a new natural or synth...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3737564/ https://ncbi.nlm.nih.gov/pubmed/23761439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt526 |
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