CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Chromosome segregation relies on centromeres, yet their repetitive DNA is often prone to aberrant rearrangements under pathological conditions. Factors that maintain centromere integrity to prevent centromere-associated chromosome translocations are unknown. Here, we demonstrate the importance of th...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Giunta, Simona, Hervé, Solène, White, Ryan R., Wilhelm, Therese, Dumont, Marie, Scelfo, Andrea, Gamba, Riccardo, Wong, Cheng Kit, Rancati, Giulia, Smogorzewska, Agata, Funabiki, Hironori, Fachinetti, Daniele
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958389/
https://ncbi.nlm.nih.gov/pubmed/33653953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015634118
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