CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Chromosome segregation relies on centromeres, yet their repetitive DNA is often prone to aberrant rearrangements under pathological conditions. Factors that maintain centromere integrity to prevent centromere-associated chromosome translocations are unknown. Here, we demonstrate the importance of th...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Giunta, Simona, Hervé, Solène, White, Ryan R., Wilhelm, Therese, Dumont, Marie, Scelfo, Andrea, Gamba, Riccardo, Wong, Cheng Kit, Rancati, Giulia, Smogorzewska, Agata, Funabiki, Hironori, Fachinetti, Daniele
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2021
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958389/
https://ncbi.nlm.nih.gov/pubmed/33653953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015634118
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