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Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis

SIMPLE SUMMARY: Chromosome instability (CIN) promotes cancer initiation and progression, but its genetic origins remain largely unknown. As aberrant mitotic processes such as chromatin compaction defects can induce CIN, characterizing the molecular determinants of mitotic fidelity may reveal novel C...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancers (Basel)
Prif Awduron: Jeusset, Lucile M., Guppy, Brent J., Lichtensztejn, Zelda, McDonald, Darin, McManus, Kirk J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958346/
https://ncbi.nlm.nih.gov/pubmed/33801331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13051043
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