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Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes

Chromosome instability (CIN), or continual changes in chromosome complements, is an enabling feature of cancer; however, the molecular determinants of CIN remain largely unknown. Emerging data now suggest that aberrant sister chromatid cohesion may induce CIN and contribute to cancer. To explore thi...

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Vydáno v:Sci Rep
Hlavní autoři: Leylek, Tarik R., Jeusset, Lucile M., Lichtensztejn, Zelda, McManus, Kirk J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969069/
https://ncbi.nlm.nih.gov/pubmed/31953484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57530-9
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