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Chloride-dependent conformational changes in the GlyT1 glycine transporter

The human GlyT1 glycine transporter requires chloride for its function. However, the mechanism by which Cl(−) exerts its influence is unknown. To examine the role that Cl(−) plays in the transport cycle, we measured the effect of Cl(−) on both glycine binding and conformational changes. The ability...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zhang, Yuan-Wei, Uchendu, Stacy, Leone, Vanessa, Bradshaw, Richard T., Sangwa, Ntumba, Forrest, Lucy R., Rudnick, Gary
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958241/
https://ncbi.nlm.nih.gov/pubmed/33658361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017431118
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