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Fluoxetine (Prozac) Binding to Serotonin Transporter Is Modulated by Chloride and Conformational Changes
Serotonin transporter (SERT) is the main target for widely used antidepressant agents. Several of these drugs, including imipramine, citalopram, sertraline, and fluoxetine (Prozac), bound more avidly to SERT in the presence of Cl(−). In contrast, Cl(−) did not enhance cocaine or paroxetine binding....
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Society for Neuroscience
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012355/ https://ncbi.nlm.nih.gov/pubmed/19641126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0440-09.2009 |
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