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Fluoxetine (Prozac) Binding to Serotonin Transporter Is Modulated by Chloride and Conformational Changes

Serotonin transporter (SERT) is the main target for widely used antidepressant agents. Several of these drugs, including imipramine, citalopram, sertraline, and fluoxetine (Prozac), bound more avidly to SERT in the presence of Cl(−). In contrast, Cl(−) did not enhance cocaine or paroxetine binding....

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Main Authors: Tavoulari, Sotiria, Forrest, Lucy R., Rudnick, Gary
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012355/
https://ncbi.nlm.nih.gov/pubmed/19641126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0440-09.2009
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