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Fluoxetine (Prozac) Binding to Serotonin Transporter Is Modulated by Chloride and Conformational Changes

Serotonin transporter (SERT) is the main target for widely used antidepressant agents. Several of these drugs, including imipramine, citalopram, sertraline, and fluoxetine (Prozac), bound more avidly to SERT in the presence of Cl(−). In contrast, Cl(−) did not enhance cocaine or paroxetine binding....

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Bibliographic Details
Main Authors: Tavoulari, Sotiria, Forrest, Lucy R., Rudnick, Gary
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012355/
https://ncbi.nlm.nih.gov/pubmed/19641126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0440-09.2009
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