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Fluoxetine (Prozac) Binding to Serotonin Transporter Is Modulated by Chloride and Conformational Changes

Serotonin transporter (SERT) is the main target for widely used antidepressant agents. Several of these drugs, including imipramine, citalopram, sertraline, and fluoxetine (Prozac), bound more avidly to SERT in the presence of Cl(−). In contrast, Cl(−) did not enhance cocaine or paroxetine binding....

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tavoulari, Sotiria, Forrest, Lucy R., Rudnick, Gary
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012355/
https://ncbi.nlm.nih.gov/pubmed/19641126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0440-09.2009
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