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Fibrinogen Interaction with Astrocyte ICAM-1 and PrP(C) Results in the Generation of ROS and Neuronal Death

Many neuroinflammatory diseases, like traumatic brain injury (TBI), are associated with an elevated level of fibrinogen and short-term memory (STM) impairment. We found that during TBI, extravasated fibrinogen deposited in vasculo-astrocyte interfaces, which was associated with neurodegeneration and...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Sulimai, Nurul, Brown, Jason, Lominadze, David
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957521/
https://ncbi.nlm.nih.gov/pubmed/33673626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052391
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