Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence

The IκB kinase (IKK)‐NF‐κB pathway is activated as part of the DNA damage response and controls both inflammation and resistance to apoptosis. How these distinct functions are achieved remained unknown. We demonstrate here that DNA double‐strand breaks elicit two subsequent phases of NF‐κB activatio...

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Publicat a:EMBO J
Autors principals: Kolesnichenko, Marina, Mikuda, Nadine, Höpken, Uta E, Kärgel, Eva, Uyar, Bora, Tufan, Ahmet Bugra, Milanovic, Maja, Sun, Wei, Krahn, Inge, Schleich, Kolja, von Hoff, Linda, Hinz, Michael, Willenbrock, Michael, Jungmann, Sabine, Akalin, Altuna, Lee, Soyoung, Schmidt‐Ullrich, Ruth, Schmitt, Clemens A, Scheidereit, Claus
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957429/
https://ncbi.nlm.nih.gov/pubmed/33459422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104296
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