Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence

The IκB kinase (IKK)‐NF‐κB pathway is activated as part of the DNA damage response and controls both inflammation and resistance to apoptosis. How these distinct functions are achieved remained unknown. We demonstrate here that DNA double‐strand breaks elicit two subsequent phases of NF‐κB activatio...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO J
Egile Nagusiak: Kolesnichenko, Marina, Mikuda, Nadine, Höpken, Uta E, Kärgel, Eva, Uyar, Bora, Tufan, Ahmet Bugra, Milanovic, Maja, Sun, Wei, Krahn, Inge, Schleich, Kolja, von Hoff, Linda, Hinz, Michael, Willenbrock, Michael, Jungmann, Sabine, Akalin, Altuna, Lee, Soyoung, Schmidt‐Ullrich, Ruth, Schmitt, Clemens A, Scheidereit, Claus
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2021
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957429/
https://ncbi.nlm.nih.gov/pubmed/33459422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104296
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