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Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein
Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del, causes misfolding and premature degradation of CFTR protein. This defect can be overcome with pharmacological agents named “correctors”. So far, a...
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| Publicat a: | Molecules |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7956813/ https://ncbi.nlm.nih.gov/pubmed/33652850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26051275 |
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