Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein

Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del, causes misfolding and premature degradation of CFTR protein. This defect can be overcome with pharmacological agents named “correctors”. So far, a...

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Udgivet i:Molecules
Main Authors: Spanò, Virginia, Barreca, Marilia, Cilibrasi, Vincenzo, Genovese, Michele, Renda, Mario, Montalbano, Alessandra, Galietta, Luis Juan Vicente, Barraja, Paola
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956813/
https://ncbi.nlm.nih.gov/pubmed/33652850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26051275
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