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Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein
Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del, causes misfolding and premature degradation of CFTR protein. This defect can be overcome with pharmacological agents named “correctors”. So far, a...
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| 出版年: | Molecules |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2021
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7956813/ https://ncbi.nlm.nih.gov/pubmed/33652850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26051275 |
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