ARID1A mutation may define an immunologically active subgroup in patients with microsatellite-stable colorectal cancer

INTRODUCTION: ARID1A is commonly mutated in colorectal cancer (CRC), frequently resulting in truncation and loss of protein expression. ARID1A recruits MSH2 for mismatch-repair during DNA replication. ARID1A deficiency promotes hypermutability and immune activation in preclinical models but its role...

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Udgivet i:Clin Cancer Res
Main Authors: Mehrvarz Sarshekeh, Amir, Alshenaifi, Jumanah, Roszik, Jason, Manyam, Ganiraju C., Advani, Shailesh M., Katkhuda, Riham, Verma, Anuj, Lam, Michael, Willis, Jason, Shen, John Paul, Morris, Jeffrey, Davis, Jennifer S., Loree, Jonathan M., Lee, Hey Min, Ajani, Jaffer A., Maru, Dipen M., Overman, Michael J., Kopetz, Scott
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956157/
https://ncbi.nlm.nih.gov/pubmed/33414133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2404
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