Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer

SMAD4 is an essential mediator in the transforming growth factor-β pathway. Sporadic mutations of SMAD4 are present in 2.1–20.0% of colorectal cancers (CRCs) but data are limited. In this study, we aimed to evaluate clinicopathologic characteristics, prognosis, and clinical outcome associated with t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sarshekeh, Amir Mehrvarz, Advani, Shailesh, Overman, Michael J., Manyam, Ganiraju, Kee, Bryan K., Fogelman, David R., Dasari, Arvind, Raghav, Kanwal, Vilar, Eduardo, Manuel, Shanequa, Shureiqi, Imad, Wolff, Robert A., Patel, Keyur P., Luthra, Raja, Shaw, Kenna, Eng, Cathy, Maru, Dipen M., Routbort, Mark J., Meric-Bernstam, Funda, Kopetz, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340382/
https://ncbi.nlm.nih.gov/pubmed/28267766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173345
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