ARID1A mutation may define an immunologically active subgroup in patients with microsatellite-stable colorectal cancer

INTRODUCTION: ARID1A is commonly mutated in colorectal cancer (CRC), frequently resulting in truncation and loss of protein expression. ARID1A recruits MSH2 for mismatch-repair during DNA replication. ARID1A deficiency promotes hypermutability and immune activation in preclinical models but its role...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Mehrvarz Sarshekeh, Amir, Alshenaifi, Jumanah, Roszik, Jason, Manyam, Ganiraju C., Advani, Shailesh M., Katkhuda, Riham, Verma, Anuj, Lam, Michael, Willis, Jason, Shen, John Paul, Morris, Jeffrey, Davis, Jennifer S., Loree, Jonathan M., Lee, Hey Min, Ajani, Jaffer A., Maru, Dipen M., Overman, Michael J., Kopetz, Scott
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956157/
https://ncbi.nlm.nih.gov/pubmed/33414133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2404
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