ARID1A mutation may define an immunologically active subgroup in patients with microsatellite-stable colorectal cancer

INTRODUCTION: ARID1A is commonly mutated in colorectal cancer (CRC), frequently resulting in truncation and loss of protein expression. ARID1A recruits MSH2 for mismatch-repair during DNA replication. ARID1A deficiency promotes hypermutability and immune activation in preclinical models but its role...

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書誌詳細
出版年:Clin Cancer Res
主要な著者: Mehrvarz Sarshekeh, Amir, Alshenaifi, Jumanah, Roszik, Jason, Manyam, Ganiraju C., Advani, Shailesh M., Katkhuda, Riham, Verma, Anuj, Lam, Michael, Willis, Jason, Shen, John Paul, Morris, Jeffrey, Davis, Jennifer S., Loree, Jonathan M., Lee, Hey Min, Ajani, Jaffer A., Maru, Dipen M., Overman, Michael J., Kopetz, Scott
フォーマット: Artigo
言語:Inglês
出版事項: 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956157/
https://ncbi.nlm.nih.gov/pubmed/33414133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2404
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