FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma

BACKGROUND: FBXW7 functions as a ubiquitin ligase tagging multiple dominant oncogenic proteins and commonly mutates in colorectal cancer. Data suggest missense mutations lead to greater loss of FBXW7 function than other gene aberrations do. However, the clinicopathologic factors and outcomes associa...

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Publicado en:Oncotarget
Autores principales: Korphaisarn, Krittiya, Morris, Van Karlyle, Overman, Michael J., Fogelman, David R., Kee, Bryan K., Kanwal Pratap Singh, Raghav, Manuel, Shanequa, Shureiqi, Imad, Wolff, Robert A., Eng, Cathy, Menter, David, Hamilton, Stanley R., Kopetz, Scott, Dasari, Arvind
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503612/
https://ncbi.nlm.nih.gov/pubmed/28424412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16848
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