FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma

BACKGROUND: FBXW7 functions as a ubiquitin ligase tagging multiple dominant oncogenic proteins and commonly mutates in colorectal cancer. Data suggest missense mutations lead to greater loss of FBXW7 function than other gene aberrations do. However, the clinicopathologic factors and outcomes associa...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Korphaisarn, Krittiya, Morris, Van Karlyle, Overman, Michael J., Fogelman, David R., Kee, Bryan K., Kanwal Pratap Singh, Raghav, Manuel, Shanequa, Shureiqi, Imad, Wolff, Robert A., Eng, Cathy, Menter, David, Hamilton, Stanley R., Kopetz, Scott, Dasari, Arvind
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503612/
https://ncbi.nlm.nih.gov/pubmed/28424412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16848
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