FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma

BACKGROUND: FBXW7 functions as a ubiquitin ligase tagging multiple dominant oncogenic proteins and commonly mutates in colorectal cancer. Data suggest missense mutations lead to greater loss of FBXW7 function than other gene aberrations do. However, the clinicopathologic factors and outcomes associa...

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Vydáno v:Oncotarget
Hlavní autoři: Korphaisarn, Krittiya, Morris, Van Karlyle, Overman, Michael J., Fogelman, David R., Kee, Bryan K., Kanwal Pratap Singh, Raghav, Manuel, Shanequa, Shureiqi, Imad, Wolff, Robert A., Eng, Cathy, Menter, David, Hamilton, Stanley R., Kopetz, Scott, Dasari, Arvind
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503612/
https://ncbi.nlm.nih.gov/pubmed/28424412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16848
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