High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). NNMT overexpression has been linked to diabetes, obesity, and various cancers. In this work, structure-based rational design led to the development of potent an...

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Bibliografski detalji
Izdano u:J Med Chem
Glavni autori: Policarpo, Rocco L., Decultot, Ludovic, May, Elizabeth, Kuzmič, Petr, Carlson, Samuel, Huang, Danny, Chu, Vincent, Wright, Brandon A., Dhakshinamoorthy, Saravanakumar, Kannt, Aimo, Rani, Shilpa, Dittakavi, Sreekanth, Panarese, Joseph D., Gaudet, Rachelle, Shair, Matthew D.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955893/
https://ncbi.nlm.nih.gov/pubmed/31589440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01238
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