Načítá se...

High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). NNMT overexpression has been linked to diabetes, obesity, and various cancers. In this work, structure-based rational design led to the development of potent an...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	J Med Chem
Hlavní autoři:	Policarpo, Rocco L., Decultot, Ludovic, May, Elizabeth, Kuzmič, Petr, Carlson, Samuel, Huang, Danny, Chu, Vincent, Wright, Brandon A., Dhakshinamoorthy, Saravanakumar, Kannt, Aimo, Rani, Shilpa, Dittakavi, Sreekanth, Panarese, Joseph D., Gaudet, Rachelle, Shair, Matthew D.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2019
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7955893/ https://ncbi.nlm.nih.gov/pubmed/31589440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01238
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo otaguje tento záznam!

High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

Podobné jednotky