High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). NNMT overexpression has been linked to diabetes, obesity, and various cancers. In this work, structure-based rational design led to the development of potent an...

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Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Policarpo, Rocco L., Decultot, Ludovic, May, Elizabeth, Kuzmič, Petr, Carlson, Samuel, Huang, Danny, Chu, Vincent, Wright, Brandon A., Dhakshinamoorthy, Saravanakumar, Kannt, Aimo, Rani, Shilpa, Dittakavi, Sreekanth, Panarese, Joseph D., Gaudet, Rachelle, Shair, Matthew D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955893/
https://ncbi.nlm.nih.gov/pubmed/31589440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01238
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