High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). NNMT overexpression has been linked to diabetes, obesity, and various cancers. In this work, structure-based rational design led to the development of potent an...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Policarpo, Rocco L., Decultot, Ludovic, May, Elizabeth, Kuzmič, Petr, Carlson, Samuel, Huang, Danny, Chu, Vincent, Wright, Brandon A., Dhakshinamoorthy, Saravanakumar, Kannt, Aimo, Rani, Shilpa, Dittakavi, Sreekanth, Panarese, Joseph D., Gaudet, Rachelle, Shair, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955893/
https://ncbi.nlm.nih.gov/pubmed/31589440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01238
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