Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) is associated with inflammatory response but it is unknown whether it is associated with alterations in NNMT activity and MNA plasma concentration. Here we examined changes in NNMT-MNA pathway in PAH in rats and humans. METHODS: PAH in rats was induc...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Fedorowicz, Andrzej, Mateuszuk, Łukasz, Kopec, Grzegorz, Skórka, Tomasz, Kutryb-Zając, Barbara, Zakrzewska, Agnieszka, Walczak, Maria, Jakubowski, Andrzej, Łomnicka, Magdalena, Słomińska, Ewa, Chlopicki, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007701/
https://ncbi.nlm.nih.gov/pubmed/27581040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0423-7
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