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HNO to NO Conversion Mechanism via Copper Zinc Superoxide Dismutase (CuZnSOD), Comparison with Heme Protein Mediated Conversions, and Origin of the Questionable Reversibility

Conversion between NO and HNO via CuZnSOD is important in biomedicine and for HNO detection. Many mechanistic questions, including the decades-long debate on reversibility, were resolved in this work. Calculations of various active site and full protein models show that the basic mechanism is proton...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Shi, Yelu, Michael, Matthew A., Zhang, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954974/
https://ncbi.nlm.nih.gov/pubmed/33398888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202100015
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