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DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7
The committed step of eukaryotic DNA replication occurs when the pairs of Mcm2-7 replicative helicases that license each replication origin are activated. Helicase activation requires the recruitment of Cdc45 and GINS to Mcm2-7, forming Cdc45-Mcm2-7-GINS complexes (CMGs). Using single-molecule bioch...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7954526/ https://ncbi.nlm.nih.gov/pubmed/33616038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65471 |
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