The structural basis for MCM2–7 helicase activation by GINS and Cdc45

Two central steps for initiating eukaryotic DNA replication involve loading of the Mcm2–7 helicase onto double-stranded DNA and its activation by GINS–Cdc45. To better understand these events, we determined the structures of Mcm2–7 and the CMG complex by using single-particle electron microscopy. Mc...

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Библиографические подробности
Главные авторы: Costa, Alessandro, Ilves, Ivar, Tamberg, Nele, Petojevic, Tatjana, Nogales, Eva, Botchan, Michael R, Berger, James M
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184033/
https://ncbi.nlm.nih.gov/pubmed/21378962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2004
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