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The structural basis for MCM2–7 helicase activation by GINS and Cdc45
Two central steps for initiating eukaryotic DNA replication involve loading of the Mcm2–7 helicase onto double-stranded DNA and its activation by GINS–Cdc45. To better understand these events, we determined the structures of Mcm2–7 and the CMG complex by using single-particle electron microscopy. Mc...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4184033/ https://ncbi.nlm.nih.gov/pubmed/21378962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2004 |
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