Surface-directed engineering of tissue anisotropy in microphysiological models of musculoskeletal tissue

Here, we present an approach to model and adapt the mechanical regulation of morphogenesis that uses contractile cells as sculptors of engineered tissue anisotropy in vitro. Our method uses heterobifunctional cross-linkers to create mechanical boundary constraints that guide surface-directed sculpti...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Mondrinos, Mark J., Alisafaei, Farid, Yi, Alex Y., Ahmadzadeh, Hossein, Lee, Insu, Blundell, Cassidy, Seo, Jeongyun, Osborn, Matthew, Jeon, Tae-Joon, Kim, Sun Min, Shenoy, Vivek B., Huh, Dongeun
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954445/
https://ncbi.nlm.nih.gov/pubmed/33712463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe9446
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