Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis

Pathogenic muscle-specific tyrosine kinase (MuSK)–specific IgG4 autoantibodies in autoimmune myasthenia gravis (MG) are functionally monovalent as a result of Fab-arm exchange. The development of these unique autoantibodies is not well understood. We examined MG patient–derived monoclonal autoantibo...

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Udgivet i:J Exp Med
Main Authors: Fichtner, Miriam L., Vieni, Casey, Redler, Rachel L., Kolich, Ljuvica, Jiang, Ruoyi, Takata, Kazushiro, Stathopoulos, Panos, Suarez, Pablo A., Nowak, Richard J., Burden, Steven J., Ekiert, Damian C., O’Connor, Kevin C.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953735/
https://ncbi.nlm.nih.gov/pubmed/32820331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200513
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