Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis

Pathogenic muscle-specific tyrosine kinase (MuSK)–specific IgG4 autoantibodies in autoimmune myasthenia gravis (MG) are functionally monovalent as a result of Fab-arm exchange. The development of these unique autoantibodies is not well understood. We examined MG patient–derived monoclonal autoantibo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Med
Egile Nagusiak: Fichtner, Miriam L., Vieni, Casey, Redler, Rachel L., Kolich, Ljuvica, Jiang, Ruoyi, Takata, Kazushiro, Stathopoulos, Panos, Suarez, Pablo A., Nowak, Richard J., Burden, Steven J., Ekiert, Damian C., O’Connor, Kevin C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953735/
https://ncbi.nlm.nih.gov/pubmed/32820331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200513
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