Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis

Pathogenic muscle-specific tyrosine kinase (MuSK)–specific IgG4 autoantibodies in autoimmune myasthenia gravis (MG) are functionally monovalent as a result of Fab-arm exchange. The development of these unique autoantibodies is not well understood. We examined MG patient–derived monoclonal autoantibo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Fichtner, Miriam L., Vieni, Casey, Redler, Rachel L., Kolich, Ljuvica, Jiang, Ruoyi, Takata, Kazushiro, Stathopoulos, Panos, Suarez, Pablo A., Nowak, Richard J., Burden, Steven J., Ekiert, Damian C., O’Connor, Kevin C.
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953735/
https://ncbi.nlm.nih.gov/pubmed/32820331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200513
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