Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity

Posttranslational modification with SUMO is known to regulate the activity of transcription factors, but how SUMOylation of individual proteins might influence immunity is largely unexplored. The NFAT transcription factors play an essential role in antigen receptor-mediated gene regulation. SUMOylat...

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Publicado en:J Exp Med
Main Authors: Xiao, Yin, Qureischi, Musga, Dietz, Lena, Vaeth, Martin, Vallabhapurapu, Subrahmanya D., Klein-Hessling, Stefan, Klein, Matthias, Liang, Chunguang, König, Anika, Serfling, Edgar, Mottok, Anja, Bopp, Tobias, Rosenwald, Andreas, Buttmann, Mathias, Berberich, Ingolf, Beilhack, Andreas, Berberich-Siebelt, Friederike
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953626/
https://ncbi.nlm.nih.gov/pubmed/32986812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181853
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