NFATc1 controls the cytotoxicity of CD8(+) T cells

Cytotoxic T lymphocytes are effector CD8(+) T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of Nfatc1 (−/−) cytotoxic T lymphocytes showed a defective cytoskeleton organizati...

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Pubblicato in:Nat Commun
Autori principali: Klein-Hessling, Stefan, Muhammad, Khalid, Klein, Matthias, Pusch, Tobias, Rudolf, Ronald, Flöter, Jessica, Qureischi, Musga, Beilhack, Andreas, Vaeth, Martin, Kummerow, Carsten, Backes, Christian, Schoppmeyer, Rouven, Hahn, Ulrike, Hoth, Markus, Bopp, Tobias, Berberich-Siebelt, Friederike, Patra, Amiya, Avots, Andris, Müller, Nora, Schulze, Almut, Serfling, Edgar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593830/
https://ncbi.nlm.nih.gov/pubmed/28894104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00612-6
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