Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity

Posttranslational modification with SUMO is known to regulate the activity of transcription factors, but how SUMOylation of individual proteins might influence immunity is largely unexplored. The NFAT transcription factors play an essential role in antigen receptor-mediated gene regulation. SUMOylat...

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Gepubliceerd in:J Exp Med
Hoofdauteurs: Xiao, Yin, Qureischi, Musga, Dietz, Lena, Vaeth, Martin, Vallabhapurapu, Subrahmanya D., Klein-Hessling, Stefan, Klein, Matthias, Liang, Chunguang, König, Anika, Serfling, Edgar, Mottok, Anja, Bopp, Tobias, Rosenwald, Andreas, Buttmann, Mathias, Berberich, Ingolf, Beilhack, Andreas, Berberich-Siebelt, Friederike
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953626/
https://ncbi.nlm.nih.gov/pubmed/32986812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181853
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