Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity

Posttranslational modification with SUMO is known to regulate the activity of transcription factors, but how SUMOylation of individual proteins might influence immunity is largely unexplored. The NFAT transcription factors play an essential role in antigen receptor-mediated gene regulation. SUMOylat...

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Vydáno v:J Exp Med
Hlavní autoři: Xiao, Yin, Qureischi, Musga, Dietz, Lena, Vaeth, Martin, Vallabhapurapu, Subrahmanya D., Klein-Hessling, Stefan, Klein, Matthias, Liang, Chunguang, König, Anika, Serfling, Edgar, Mottok, Anja, Bopp, Tobias, Rosenwald, Andreas, Buttmann, Mathias, Berberich, Ingolf, Beilhack, Andreas, Berberich-Siebelt, Friederike
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953626/
https://ncbi.nlm.nih.gov/pubmed/32986812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181853
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