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The E3 ligases Spsb1 and Spsb4 regulate RevErbα degradation and circadian period.

The time-dependent degradation of core circadian clock proteins is essential for the proper functioning of circadian timekeeping mechanisms that drive daily rhythms in gene expression and ultimately, an organism’s physiology. The ubiquitin proteasome system plays a critical role in regulating the st...

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Dettagli Bibliografici
Pubblicato in:J Biol Rhythms
Autori principali: Mekbib, Tsedey, Suen, Ting-Chung, Rollins-Hairston, Aisha, DeBruyne, Jason P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953592/
https://ncbi.nlm.nih.gov/pubmed/31607207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0748730419878036
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