FUS-dependent liquid–liquid phase separation is important for DNA repair initiation

RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it undergoes reversible liquid–liquid phase separation (LLPS) in vitro. Here, we demonstrate that FUS-dependent LLPS is necessary...

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Udgivet i:J Cell Biol
Main Authors: Levone, Brunno R., Lenzken, Silvia C., Antonaci, Marco, Maiser, Andreas, Rapp, Alexander, Conte, Francesca, Reber, Stefan, Mechtersheimer, Jonas, Ronchi, Antonella E., Mühlemann, Oliver, Leonhardt, Heinrich, Cardoso, M. Cristina, Ruepp, Marc-David, Barabino, Silvia M.L.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953258/
https://ncbi.nlm.nih.gov/pubmed/33704371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202008030
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