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FUS-dependent liquid–liquid phase separation is important for DNA repair initiation
RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it undergoes reversible liquid–liquid phase separation (LLPS) in vitro. Here, we demonstrate that FUS-dependent LLPS is necessary...
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| Udgivet i: | J Cell Biol |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Rockefeller University Press
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7953258/ https://ncbi.nlm.nih.gov/pubmed/33704371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202008030 |
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