FUS-dependent liquid–liquid phase separation is important for DNA repair initiation

RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it undergoes reversible liquid–liquid phase separation (LLPS) in vitro. Here, we demonstrate that FUS-dependent LLPS is necessary...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Cell Biol
Autori principali: Levone, Brunno R., Lenzken, Silvia C., Antonaci, Marco, Maiser, Andreas, Rapp, Alexander, Conte, Francesca, Reber, Stefan, Mechtersheimer, Jonas, Ronchi, Antonella E., Mühlemann, Oliver, Leonhardt, Heinrich, Cardoso, M. Cristina, Ruepp, Marc-David, Barabino, Silvia M.L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2021
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953258/
https://ncbi.nlm.nih.gov/pubmed/33704371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202008030
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi