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An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity

Epithelia are continuously self-renewed, but how epithelial integrity is maintained during the morphological changes that cells undergo in mitosis is not well understood. Here, we show that as epithelial cells round up when they enter mitosis, they exert tensile forces on neighboring cells. We find...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Monster, Jooske L., Donker, Lisa, Vliem, Marjolein J., Win, Zaw, Matthews, Helen K., Cheah, Joleen S., Yamada, Soichiro, de Rooij, Johan, Baum, Buzz, Gloerich, Martijn
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953256/
https://ncbi.nlm.nih.gov/pubmed/33688935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202001042
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