Tet1 is not required for myeloid leukemogenesis by MLL-ENL in novel mouse models

The Ten Eleven Translocation 1 (TET1) gene encodes an epigenetic modifying molecule that is involved in demethylation of 5-methylcytosine. In hematological malignancies, loss-of-function mutations of TET2, which is one of the TET family genes including TET1, are frequently found, while the mutations...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ono, Ryoichi, Masuya, Masahiro, Inoue, Naokazu, Shinmei, Makoto, Ishii, Satomi, Maegawa, Yuri, Maharjan, Bishnu Devi, Katayama, Naoyuki, Nosaka, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951824/
https://ncbi.nlm.nih.gov/pubmed/33705482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0248425
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