Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still controversial whether the MLL fusion protein is sufficient to induce acute leukemia without addition...

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Hauptverfasser: Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, Kitamura, Toshio, Hayashi, Yasuhide, Nosaka, Tetsuya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1062890/
https://ncbi.nlm.nih.gov/pubmed/15761502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522725
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