Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still controversial whether the MLL fusion protein is sufficient to induce acute leukemia without addition...

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Main Authors: Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, Kitamura, Toshio, Hayashi, Yasuhide, Nosaka, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1062890/
https://ncbi.nlm.nih.gov/pubmed/15761502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522725
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