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The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases

Cullin RING E3 ligases (CRLs) ubiquitylate hundreds of important cellular substrates. Here we have assembled and purified the Ankyrin repeat and SOCS Box protein 9 CUL5 RBX2 ligase (ASB9-CRL) in vitro and show how it ubiquitylates one of its substrates, CKB. CRLs occasionally collaborate with RING b...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell Proteomics
Egile Nagusiak: Lumpkin, Ryan J., Ahmad, Alla S., Blake, Rachel, Condon, Christopher J., Komives, Elizabeth A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2021
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7950132/
https://ncbi.nlm.nih.gov/pubmed/33268465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002414
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