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The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases
Cullin RING E3 ligases (CRLs) ubiquitylate hundreds of important cellular substrates. Here we have assembled and purified the Ankyrin repeat and SOCS Box protein 9 CUL5 RBX2 ligase (ASB9-CRL) in vitro and show how it ubiquitylates one of its substrates, CKB. CRLs occasionally collaborate with RING b...
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| Publicado no: | Mol Cell Proteomics |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7950132/ https://ncbi.nlm.nih.gov/pubmed/33268465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002414 |
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