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The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases
Cullin RING E3 ligases (CRLs) ubiquitylate hundreds of important cellular substrates. Here we have assembled and purified the Ankyrin repeat and SOCS Box protein 9 CUL5 RBX2 ligase (ASB9-CRL) in vitro and show how it ubiquitylates one of its substrates, CKB. CRLs occasionally collaborate with RING b...
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| Pubblicato in: | Mol Cell Proteomics |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7950132/ https://ncbi.nlm.nih.gov/pubmed/33268465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002414 |
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