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SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing
Sirtuin 1 (SIRT1) is a protein deacetylase that maintains genome stability by preventing the activation of latent replication origins. Amplified genes in cancer cells localize on either extrachromosomal double minutes (DMs) or the chromosomal homogeneously staining region. Previously, we found that...
Enregistré dans:
| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7949162/ https://ncbi.nlm.nih.gov/pubmed/33539925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100356 |
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