Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability

Chromatin structure affects DNA replication patterns, but the role of specific chromatin modifiers in regulating the replication process is yet unclear. We report that phosphorylation of the human SIRT1 deacetylase on Threonine 530 (T530-pSIRT1) modulates DNA synthesis. T530-pSIRT1 associates with r...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Utani, Koichi, Fu, Haiqing, Jang, Sang-Min, Marks, Anna B., Smith, Owen K., Zhang, Ya, Redon, Christophe E., Shimizu, Noriaki, Aladjem, Mirit I.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570034/
https://ncbi.nlm.nih.gov/pubmed/28549174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx468
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