Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability

Chromatin structure affects DNA replication patterns, but the role of specific chromatin modifiers in regulating the replication process is yet unclear. We report that phosphorylation of the human SIRT1 deacetylase on Threonine 530 (T530-pSIRT1) modulates DNA synthesis. T530-pSIRT1 associates with r...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Utani, Koichi, Fu, Haiqing, Jang, Sang-Min, Marks, Anna B., Smith, Owen K., Zhang, Ya, Redon, Christophe E., Shimizu, Noriaki, Aladjem, Mirit I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570034/
https://ncbi.nlm.nih.gov/pubmed/28549174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx468
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky