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KCC2 is required for the survival of mature neurons but not for their development
The K(+)/Cl(−) cotransporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl(−) levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors (GABA(A)Rs). In accordance with this, compromised KCC2 activity res...
Enregistré dans:
| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7949141/ https://ncbi.nlm.nih.gov/pubmed/33539918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100364 |
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