KCC2 is required for the survival of mature neurons but not for their development

The K(+)/Cl(−) cotransporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl(−) levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors (GABA(A)Rs). In accordance with this, compromised KCC2 activity res...

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Publicado en:J Biol Chem
Autores principales: Kontou, Georgina, Josephine Ng, Shu Fun, Cardarelli, Ross A., Howden, Jack H., Choi, Catherine, Ren, Qiu, Rodriguez Santos, Miguel A., Bope, Christopher E., Dengler, Jake S., Kelley, Matt R., Davies, Paul A., Kittler, Josef T., Brandon, Nicholas J., Moss, Stephen J., Smalley, Joshua L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949141/
https://ncbi.nlm.nih.gov/pubmed/33539918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100364
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