KCC2 is required for the survival of mature neurons but not for their development

The K(+)/Cl(−) cotransporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl(−) levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors (GABA(A)Rs). In accordance with this, compromised KCC2 activity res...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Kontou, Georgina, Josephine Ng, Shu Fun, Cardarelli, Ross A., Howden, Jack H., Choi, Catherine, Ren, Qiu, Rodriguez Santos, Miguel A., Bope, Christopher E., Dengler, Jake S., Kelley, Matt R., Davies, Paul A., Kittler, Josef T., Brandon, Nicholas J., Moss, Stephen J., Smalley, Joshua L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2021
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949141/
https://ncbi.nlm.nih.gov/pubmed/33539918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100364
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items