Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy

Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K(+)/Cl(−) co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic inhibition and deficits in its activity are obser...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Kelley, Matt R., Cardarelli, Ross A., Smalley, Joshua L., Ollerhead, Thomas A., Andrew, Peter M., Brandon, Nicholas J., Deeb, Tarek Z., Moss, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020795/
https://ncbi.nlm.nih.gov/pubmed/29884458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.05.029
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